Fig 2. Mouse Igf2 and human IGF2 mRNAs and proteins.
A, B. Depiction of the 4 major species of mouse Igf2 transcripts (A) and the 6 major types of human IGF2 mRNAs (B). The responsible promoters (p for mouse, P for human) are listed, as are the exons found in each transcript. The length of each mRNA is in nucleotides (nt). AN represents the polyadenylic acid tail found at the 3’ end of mRNAs. C. Depiction of mouse and human IGF2 protein precursors, showing the derivation of each segment from different Igf2 or IGF2 exons. Mature, 67-amino acid IGF2 is in blue; presumed and confirmed signal peptides (SP) are in black, and the 89-amino acid E peptide is in red. Amino acid is abbreviated as AA.