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. 2019 Jun 28;15(6):e1008214. doi: 10.1371/journal.pgen.1008214

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© 2019 Yun et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — (A) Survival of pups born to TDAG51^-/- dams. The photographs were obtained on postnatal day 1 (P1). Arrowheads indicate dead pups. Dotted circles indicate pups gathered in a nest. +/+, TDAG51^+/+ dams. +/-, TDAG51^+/- dams. -/-, TDAG51^-/- dams. (B) The average number of pups born to TDAG51^-/- dams. The number of pups per dam was analyzed on P0. Black bar (+/+), TDAG51^+/+ dams. Gray bar (+/-), TDAG51^+/- dams. White bar (-/-), TDAG51^-/- dams. (C) The survival rate of pups born to TDAG51^-/- dams. Pup survival was measured from P0 to P2 in the absence of male mating partners. (D) The survival rate of pups with surrogate TDAG51^-/- dams. A schematic diagram of the cross-fostering experiment between TDAG51^+/+ and TDAG51^-/- dams is shown in the left panel. Pups born to TDAG51^+/+ and TDAG51^-/- dams were interchanged on P0, and the survival of the cross-fostered pups with their surrogate dams was analyzed on P2. Black bar (+/+), TDAG51^+/+ surrogate dams. White bar (-/-), TDAG51^-/- surrogate dams. (E) The effect of male mating partners on the survival of pups born to TDAG51^-/- dams. Pup survival was analyzed from P0 to P2 in the presence of the male mating partner. Black bar, TDAG51^-/- dams with TDAG51^+/+ male mice. White bar, TDAG51^-/- dams with TDAG51^-/- male mice. **p<0.01. n.s., not significant.