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. 2019 Jun 28;15(6):e1008214. doi: 10.1371/journal.pgen.1008214

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© 2019 Yun et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 5 — (A) Impaired expression of OXT and its receptor OXTR in TDAG51^-/- dams after parturition. Total RNA isolated from brain tissues was analyzed by real-time PCR using specific primers. N.P., nonpregnant mice. Black bar (+/+), TDAG51^+/+ dams. White bar (-/-), TDAG51^-/- dams. Gray bar (-/-^Tg2), TDAG51^-/-Tg2 dams. (B) Serum OXT levels in TDAG51^-/- dams after parturition. Serum OXT levels were analyzed using ELISA. (C) No difference in ESR1 expression was observed in the TDAG51^-/- dams. (D) No difference in the serum estrogen levels was observed in the TDAG51^-/- dams. Serum estrogen (17-β-estradiol) levels after parturition were analyzed using ELISA. (E) Downregulation of AVP expression in TDAG51^-/- dams after parturition. (F) Downregulation of BDNF expression in TDAG51^-/- dams after parturition. (G) Downregulation of PDYN expression in TDAG51^-/- dams after parturition. (H) Downregulation of NPY and its receptor NPY1R expression in TDAG51^-/- dams after parturition. (I) Downregulation of PENK and its receptor OPRD1 expression in TDAG51^-/- dams after parturition. (J) Upregulation of PRL expression in TDAG51^-/- dams after parturition. (K) Upregulation of CRHR1 expression in TDAG51^-/- dams after parturition. *p<0.05. **p<0.01. n.s., not significant.