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. 2019 Jun 28;15(6):e1008214. doi: 10.1371/journal.pgen.1008214

Fig 6. Altered gene expression in the brain tissue of TDAG51-/- dams after parturition.

Fig 6

(A) Prediction of the functional networks of the 39 downregulated genes listed in Table 1. Node color intensity indicates the degree of the downregulation of gene expression as follows: a greater intensity of green represents a higher degree of downregulation. Inverted triangle, kinase; dotted square, growth factor; vertical rectangle, G-protein coupled receptor; dotted vertical rectangle, ion channel; horizontal rectangle, ligand-dependent nuclear receptor; vertical diamond, enzyme; trapezoid, transporter; horizontal ellipse, transcription regulator; circle, other. (B) Prediction of the functional networks of the 31 upregulated genes listed in Table 2. Node color intensity indicates the degree of the upregulation of gene expression as follows: a greater intensity of red represents a higher degree of upregulation. (C) Real-time PCR analysis of downregulated genes selected from the list shown in Table 1. Total RNA isolated from brain tissues was analyzed using real-time PCR with specific primers. Black bar (+/+), TDAG51+/+ dams. White bar (-/-), TDAG51-/- dams. Gray bar (-/-Tg2), TDAG51-/-Tg2 dams. (D) Real-time PCR analysis of upregulated genes selected from the list shown in Table 2. *p<0.05. **p<0.01.