Table 1. Downregulated genes in TDAG51-/- brain tissues after parturition.
| Fold change | |||||
|---|---|---|---|---|---|
| Symbol | Gene ID | Protein name | Category | -/- vs. +/+ |
-/- vs. -/-Tg2 |
| ADORA2A | 11540 | Adenosine A2a receptor | A, B, D | -4.9 | -4.3 |
| ARX | 11878 | Aristaless related homeobox | A, B | -4.0 | -2.1 |
| CACNA1S | 12292 | Calcium voltage-gated channel subunit alpha1 S | D | -2.3 | -2.4 |
| CCK | 12424 | Cholecystokinin | B | -3.1 | -2.6 |
| CHRM1 | 12669 | Cholinergic receptor muscarinic 1 | C, D | -6.4 | -4.7 |
| CHRM3 | 12671 | Cholinergic receptor muscarinic 3 | C, D | -3.5 | -4.7 |
| DRD1 | 13488 | Dopamine receptor D1 | C, D, E | -5.9 | -5.8 |
| DRP2 | 13497 | Dystrophin related protein 2 | D | -2.1 | -2.8 |
| EGR3 | 13655 | Early growth response 3 | A | -4.3 | -5.5 |
| ENSA | 56205 | Endosulfine alpha (alpha-endosulfine) | B | -2.2 | -2.5 |
| FKBP5 | 14229 | FK506 binding protein 5 | B, D | -2.9 | -2.1 |
| GABRA3 | 14396 | Gamma-aminobutyric acid type A (GABAA) receptor alpha3 subunit | C, D | -2.3 | -2.1 |
| GNAL | 14680 | G protein subunit alpha L | E, F | -4.7 | -2.4 |
| GPER1 | 76854 | G protein-coupled estrogen receptor 1 | C | -3.0 | -2.1 |
| GRIN2B | 14812 | Glutamate ionotropic receptor NMDA type subunit 2B | B, C, D | -2.7 | -2.7 |
| GRM5 | 108071 | Glutamate metabotropic receptor 5 (mGluR5) | B, C, D | -3.2 | -2.6 |
| HOMER1 | 26556 | Homer scaffolding protein 1 | B | -2.3 | -2.4 |
| HTR6 | 15565 | 5-Hydroxytryptamine (serotonin, 5-HT) receptor 6 (5-HT6 receptor) | C, D | -5.8 | -8.8 |
| KCNJ6 | 16522 | Potassium voltage-gated channel subfamily J member 6 | B | -22.9 | -6.0 |
| KLF9 | 16601 | Kruppel like factor 9 | B | -2.8 | -2.0 |
| MAPK1 | 26413 | Mitogen-activated protein kinase 1 | A, B, F, G | -2.2 | -2.1 |
| NPY | 109648 | Neuropeptide Y | B | -4.1 | -5.3 |
| NPY1R | 18166 | Neuropeptide Y receptor Y1 | A | -2.0 | -2.5 |
| NR2E1 | 21907 | Nuclear receptor subfamily 2 group E member 1 | A, E | -2.1 | -2.2 |
| OXTR | 18430 | Oxytocin receptor | A, C, D, E, F | -2.7 | -2.2 |
| PDE10A | 23984 | Phosphodiesterase 10A | D | -2.3 | -2.1 |
| PDE1A | 18573 | Phosphodiesterase 1A | D | -2.4 | -2.8 |
| PDE2A | 207728 | Phosphodiesterase 2A | D | -2.8 | -3.0 |
| PDYN | 18610 | Prodynorphin | B, D | -2.5 | -3.8 |
| PENK | 18619 | Proenkephalin | A, B | -2.3 | -2.5 |
| PLAUR | 18793 | Plasminogen activator, urokinase receptor | B | -3.5 | -3.6 |
| PTN | 19242 | Pleiotrophin | D | -2.2 | -2.4 |
| RASD2 | 75141 | RASD family member 2 (GTP-binding protein Rhes) | B | -3.0 | -2.3 |
| SLC17A7 | 72961 | Solute carrier family 17 member 7 (Vesicular glutamate transporter 1) | B | -2.1 | -2.7 |
| STX1A | 20907 | Syntaxin 1A | B, D | -2.9 | -2.6 |
| TAC1 | 21333 | Tachykinin precursor 1 | B, C, D | -2.7 | -3.1 |
| TSC1 | 64930 | TSC complex subunit 1 (Hamartin) | B | -3.0 | -5.2 |
| UCN3 | 83428 | Urocortin 3 | D | -2.4 | -5.9 |
| ZKSCAN1 | 74570 | Zinc finger with KRAB and SCAN domains 1 | D | -2.4 | -5.9 |
Downregulated genes in TDAG51-/- vs. TDAG51+/+ or TDAG51-/- vs. TDAG51-/-Tg2 brain tissues (P0) after parturition. Genes differentially expressed between TDAG51-/- and TDAG51+/+ control or TDAG51-/-Tg2 brain tissues were categorized by an IPA analysis with the following disease and function annotations: A, Aggressive behavior; B, Anxiety; C, Anxiety disorder; D, Depressive disorder; E, Maternal behavior; F, Maternal nurturing; and G, Nest building behavior. Gene ID, Gene identification number.