Table 2. Upregulated genes in TDAG51-/- brain tissues after parturition.
| Fold change | |||||
|---|---|---|---|---|---|
| Symbol | Gene ID | Protein name | Description | -/- vs. +/+ |
-/- vs. -/-Tg2 |
| A2M | 232345 | Alpha-2-macroglobulin | D | 3.9 | 5.2 |
| BTG1 | 12226 | BTG anti-proliferation factor 1 | D | 2.3 | 2.1 |
| CA3 | 12350 | Carbonic anhydrase 3 | C, D | 4.6 | 13.5 |
| CAMK2A | 12322 | Calcium/calmodulin dependent protein kinase II alpha | A, B, D | 2.2 | 2.2 |
| CAMK2B | 12323 | Calcium/calmodulin dependent protein kinase II beta | B, G | 3.3 | 3.4 |
| CAMK4 | 12326 | Calcium/calmodulin dependent protein kinase IV | D | 4.7 | 3.1 |
| CHRNA3 | 110834 | Cholinergic receptor nicotinic alpha 3 subunit | D | 3.9 | 2.0 |
| CHRNB3 | 108043 | Cholinergic receptor nicotinic beta 3 subunit | G | 2.2 | 2.0 |
| CNTNAP2 | 66797 | Contactin associated protein-like 2 | B | 3.9 | 3.1 |
| DAO | 13142 | D-amino acid oxidase | B | 2.2 | 2.1 |
| FEV | 260298 | ETS transcription factor | A, B | 2.2 | 7.3 |
| GABRA6 | 14399 | Gamma-aminobutyric acid type A receptor alpha6 subunit | C, D | 15.2 | 15.5 |
| GABRB3 | 14402 | Gamma-aminobutyric acid type A receptor beta3 subunit | C, D, E, G | 7.8 | 4.0 |
| GRIK1 | 14805 | Glutamate ionotropic receptor kainate type subunit 1 | C, D | 10.0 | 2.7 |
| GRN | 14824 | Granulin precursor | A, B | 2.1 | 3.0 |
| HCRTR1 | 230777 | Hypocretin receptor 1 | C, D | 2.2 | 2.3 |
| HTR7 | 15566 | 5-Hydroxytryptamine (serotonin, 5-HT) receptor 7 (5-HT7 receptor) | C, D | 2.6 | 6.4 |
| HUWE1 | 59026 | HECT, UBA and WWE domain containing 1 | D | 4.2 | 3.0 |
| MAG | 17136 | Myelin associated glycoprotein | A | 4.5 | 5.3 |
| MDFI | 17240 | MyoD family inhibitor | D | 2.4 | 3.1 |
| NCAM1 | 17967 | Neural cell adhesion molecule 1 | D | 2.1 | 2.5 |
| NFKB1 | 18033 | Nuclear factor kappa B subunit 1 (NFκB p105 subunit) | B | 2.9 | 9.2 |
| PDE9A | 18585 | Phosphodiesterase 9A | D | 4.4 | 2.7 |
| PLCB4 | 18798 | Phospholipase C beta 4 | B | 3.0 | 2.3 |
| PTEN | 320193 | Phosphatase and tensin homolog | A, E | 2.1 | 2.3 |
| SLC1A6 | 20513 | Solute carrier family 1 member 6 (high affinity Asp/Glu transporter) | C, D | 4.3 | 4.3 |
| SLC6A2 | 20538 | Solute carrier family 6 member 2 (norepinephrine transporter) | C, D | 10.8 | 11.8 |
| SLC6A4 | 15567 | Solute carrier family 6 member 4 (serotonin transporter) | A, B, C, D | 19.6 | 11.8 |
| SNAP91 | 20616 | Synaptosome associated protein 91 | B, G | 2.4 | 3.4 |
| TPH2 | 216343 | Tryptophan hydroxylase 2 | A, C, D, E, F | 10.3 | 2.8 |
| TYMS | 22171 | Thymidylate synthetase | D | 2.9 | 2.6 |
Upregulated genes in TDAG51-/- vs. TDAG51+/+ or TDAG51-/- vs. TDAG51-/-Tg2 brain tissues (P0) after parturition. Genes differentially expressed between TDAG51-/- and TDAG51+/+ control or TDAG51-/-Tg2 brain tissues were categorized by an IPA analysis with the following disease and function annotations: A, Aggressive behavior; B, Anxiety; C, Anxiety disorder; D, Depressive disorder; E, Maternal behavior; F, Maternal nurturing; and G, Nest building behavior. Gene ID, Gene identification number.