FIGURE 1.

Amino acid sequence similarity for the myeloperoxidase gene, predicted or confirmed protein isoforms across various animal species (including humans), in the context of other closely related oxidases of relevance to inflammation. Distance Phylogenetic tree, NCBI Constraint-based Multiple Alignment Tool. Elements clustered together within a given branch are more similar compared to elements in nearby branches; differences increase as branch-branch distances increase. Notice MPO sequence similarity between dogs, humans and experimental mammalian species, mice, rats, and primates.