Table 3.

Neurodevelopmental outcome in survivors by duration of any respiratory support

Duration of support (number of patients)	>1d N=92	>7d N=107	>14d N=122	>21d N=154	>28d N-1106	>60d N=717	>90d n=186	>120d N=54	P-value
No NDI (%)	98	95	94	93	90	78	65	50	<0.001*
CP (%)	5	3	7	8	10	18	21	38	<0.001*
Moderate-severe CP (%)	1	0	2	3	4	10	15	28	<0.001*
Blind (%)	0	0	0	0	1	2	3	4	<0.001*
Deaf (%)	1	2	2	2	2	5	7	15	<0.001*
BSID-III Cognitive score, mean (SD)	97.4 (12.3)	95.4 (14.3)	92.7 (12.3)	94.1 (13.2)	91.1 (14.2)	84.7 (14.9)	78.4 (16.0)	74.8 (17.0)	<0.001**
Cognitive score <70 (%)         <85 (%)	1 8	3 15	2 19	4 17	6 23	14 40	27 54	37 63	<0.001* <0.001*

Note: This table includes infants that received respiratory support for at least one day and survived to follow-up and had NDI information (n=2538). Each column represents a distinct group of infants. For instance, the column labeled as >1d contains the statistics for infants that had support for at least 1 days, but less than 7 days; and the column labeled as >7d contains the statistics for infants that had support for at least 7 days, but less than 14 days. NDI=neurodevelopmental impairment, CP=cerebral palsy.

^*Mantel-Haenszel Chi-Square Test. Additionally, Cochran-Armitage Trend Tests indicated significant increasing trends of the outcome rates with duration of respiratory support (Left-sided P-value<0.001). Exact test statistics were calculated due to small sample sizes.

^**One-way analysis of variance (ANOVA) F test.