Table 4.
Modified Canine Atopic Dermatitis Extent and Severity Index scores recorded by veterinarians during the study period
| Dermatological site | Visit | P-value | ||
|---|---|---|---|---|
| Initial | 4 weeks | 8 weeks | ||
| Dog total | 19 (3–69)a | 11 (1–51)b | 7 (3–46)bc | 0.0001 |
| Chin, Lips & Face (left and right combined) | 3 (0–8)a | 1 (0–6)b | 0 (0–5)bc | 0.0003 |
| Medial Pinnae (concave pinnae) | 2 (0–11) | 2 (0–9) | 1 (0–5) | 0.1046 |
| Axillae | 2 (0–10)a | 0 (0–6)ab | 0 (0–4)b | 0.0020 |
| Front Paws (dorsal and palmar sides combined) | 3 (0–7)a | 1 (0–4)b | 1 (0–4)ab | 0.0017 |
| Hind Paws (dorsal and plantar sides combined) | 3 (0–7) | 1 (0–7) | 1 (0–10) | 0.2224 |
| Cubital Flexor (elbow folds) | 0 (0–13) | 0 (0–4) | 0 (0–4) | 0.0490 |
| Palmar Metacarpal (from carpal to metacarpal pads) | 0 (0–4) | 0 (0–4) | 0 (0–4) | 0.1673 |
| Dorsum, Flanks & Tail Base | 0 (0–11)a | 0 (0–6)a | 0 (0–2)a | 0.0383 |
| Inguinal Areas† | 1 (0–10)a | 1 (0–6)b | 0 (0–4)ab | 0.0337 |
| Abdomen | 1 (0–10) | 1 (0–8) | 0 (0–4) | 0.1619 |
| Perineum | 0 (0–9) | 0 (0–6) | 0 (0–4) | 0.1058 |
| Ventral Tail (proximal) | 0 (0–8) | 0 (0–4) | 0 (0–4) | 0.1353 |
Legend: Modified Canine Atopic Dermatitis Extent and Severity Index scores recorded by veterinarians during the study period. Data are reported as median (range). Data were available for 17 dogs during the initial examination and at 4 weeks, and for 13 dogs at 8 weeks
a,b,c Within each row, time points with different letters are significantly different (Friedman’s chi-square with Bonferroni adjustment < 0.05)
† Statistical significance is not robust for this region (Statistical test looks at the entire distribution. For borderline cases, it is possible to have statistical significance with equal medians)