. 2019 Jun 28;15:220. doi: 10.1186/s12917-019-1929-2

Table 5.

Quality of life and skin condition as perceived by dog owners during the study period

Parameter rated	LSM (SE)/N*	Visit			P-value
Parameter rated	LSM (SE)/N*	Week 0	Week 4	Week 8	P-value
Acceptance	LSM (SE)	5.00 (0.19)	4.60 (0.19)	4.60 (0.19)	0.1408
Acceptance	N	5	5	5
Dandruff	LSM (SE)	2.82 (0.69)	1.09 (0.69)	1.91 (0.69)	0.0743
Dandruff	N	11	11	11
Disruption to family	LSM (SE)	3.18 (0.93)	2.36 (0.93)	2.36 (0.93)	0.0967
Disruption to family	N	11	11	11
Hair loss	LSM (SE)	5.91 (0.99)	4.27 (0.99)	4.55 (0.99)	0.0684
Hair loss	N	11	11	11
Head shaking	LSM (SE)	3.15 (0.82)	2.31 (0.82)	2.26 (0.84)	0.1617
Head shaking	N	13	13	11
Licking	LSM (SE)	6.31 (0.67)^a	3.46 (0.67)^b	4.06 (0.73)^ab	0.0055
Licking	N	13	13	11
Odor	LSM (SE)	2.45 (0.74)	1.73 (0.74)	1.27 (0.74)	0.0521
Odor	N	11	11	11
Overall condition of skin	LSM (SE)	4.64 (0.78)	3.45 (0.78)	3.27 (0.78)	0.1332
Overall condition of skin	N	11	11	11
Quality of life	LSM (SE)	6.86 (0.68)	6.93 (0.68)	7.51 (0.73)	0.6296
Quality of life	N	14	14	11
Redness/erythema	LSM (SE)	5.45 (0.82)^a	3.91 (0.82)^b	2.82 (0.82)^c	0.0007
Redness/erythema	N	11	11	11
Rubbing	LSM (SE)	4.85 (0.83)	4.54 (0.83)	3.82 (0.89)	0.6333
Rubbing	N	13	13	11
Scratching all skin	LSM (SE)	5.23 (0.87)^a	3.08 (0.87)^b	2.94 (0.88)^bc	0.0001
Scratching all skin	N	13	13	11
Scratching of ears	LSM (SE)	4.00 (0.87)	2.27 (0.87)	2.18 (0.87)	0.0129
Scratching of ears	N	11	11	11
Shininess of hair	LSM (SE)	3.73 (0.80)	2.73 (0.80)	3.55 (0.80)	0.2195
Shininess of hair	N	11	11	11
Softness of hair	LSM (SE)	3.64 (0.75)	2.91 (0.75)	3.27 (0.75)	0.6753
Softness of hair	N	11	11	11

Legend: Dog owner assessment scores of various quality of life and atopic dermatitis clinical signs at baseline, week 4, and week 8. *LSM = least squares mean; SE = Standard error; N = number of dogs for which data were available at each time point. ^a,b,c Within each row, time points with different letters are significantly different (Tukey’s p-value < 0.05)