Table 4.

Molecular characterization of patient-derived xenografts

Sample	MSI status	BRAF	KRAS	NRAS	MLH1	MSH2	MSH3	MSH6	PMS2	POLE
CRC106	MSI	V600E	WT	WT	WT	WT	WT	R577H / p.T1085Tfs7*	WT	WT
CRC542	MSS	WT	WT	WT	WT	WT	WT	WT	WT	WT
CRC371	MSS	WT	WT	E132K	R265C	WT	WT	E946*	WT	V411 L

*Only non-synonymous variants present in COSMIC database are reported