Table 1.
Baseline patient characteristics of patients in MESSI and PETROS cohorts
| MESSI cohort (n = 120) | PETROS cohort (n = 180) | |
|---|---|---|
| Demographics | ||
| Age, years | 61 (50–68) | 41 (25–62) |
| Male sex | 71 (59) | 140 (78) |
| Racea | ||
| White | 63 (53) | 76 (42) |
| Black | 51 (43) | 89 (49) |
| Otherb | 6 (4) | 15 (8) |
| Body mass index (kg/m2) | 26.5 (22.1–32.7) | 25.3 (22.7–28.5) |
| Medical history | ||
| Hypertensiona | 70 (58) | 50 (28) |
| Diabetes mellitusa | 45 (38) | 13 (7) |
| Congestive heart failurea | 21 (18) | 7 (4) |
| Chronic kidney diseaseac | 20 (17) | 5 (3) |
| Chronic lung diseasea | 15 (13) | 0 (0) |
| Chronic alcohol abusead | 15 (13) | 10 (6) |
| Smoking historyad | ||
| Never | 56 (47) | 66 (40) |
| Former | 27 (23) | 25 (15) |
| Current | 19 (16) | 72 (44) |
| Acute injury and illness | ||
| Blunt trauma mechanism | N/A | 137 (76) |
| Injury Severity Score | N/A | 25 (19–30) |
| Operation prior to ICU admission | N/A | 74 (41) |
| APACHE II | 29 (21–37) | 17 (12–24) |
| Shock prior to ICU admissionae | 93 (78) | 89 (50) |
| Crystalloid, litersadf | 3.5 (2.0–6.9) | 2.5 (1.2–4.0) |
| Pulmonary source of sepsis | 51 (43) | N/A |
| Transfusions (days 0 + 1)g | ||
| Received RBC transfusion | 31 (26) | 108 (60) |
| Number of units | 2 (1–2) | 5 (3–9) |
| Received FFP transfusion | 16 (13) | 67 (37) |
| Number of units | 3 (2–4) | 4 (2–6) |
| Received platelet transfusion | 18 (15) | 62 (34) |
| Number of dosesh | 2 (1–3) | 2 (1–2) |
| Outcomes | ||
| ARDS | 44 (37) | 37 (21) |
| AKIi | 41 (37) | 53 (30) |
| 30-day mortality | 50 (42) | 17 (9) |
Data are shown as n (%) for categorical variables and median (interquartile range) for continuous variables. Definition of abbreviations: ARDS acute respiratory distress syndrome, SBP systolic blood pressure, ED emergency department, ICU intensive care unit, RBC red blood cell, FFP fresh frozen plasma. aMissing data for PETROS cohort: race (n = 4); hypertension [4]; diabetes [3]; coronary heart disease [3]; congestive heart failure [2]; chronic kidney disease [1]; chronic lung disease [1]; chronic alcohol abuse [5]; smoking history [17]; shock prior to ICU admission [1]; crystalloid [4]. bIn PETROS cohort, Asian (n = 9), North American Indian/Alaskan Native (n = 2), and Unknown (n = 2); in MESSI cohort, Asian (n = 1) and unknown (n = 5). cIncludes patients with end-stage renal disease (MESSI n = 9, PETROS n = 1). dMissing data for MESSI cohort: chronic alcohol abuse (n = 19); smoking history [18]; crystalloid [2]. eShock defined as need for vasopressors or mean arterial pressure < 65 mmHg (MESSI) or systolic arterial pressure < 90 mmHg (PETROS). fAdministered during the first 24 h after ED presentation (MESSI) or prior to ICU arrival (PETROS). gThe calendar day of and the day after presentation. hEach platelet dose at our institution is roughly equivalent to 4 single-donor platelet units or 6 pooled platelet units. iAKI numbers exclude patients with end-stage renal disease