Table 1.

Results of initial laboratory tests

Parameters	Parameter Value	Reference interval
Sodium (mmol/L)	138	135–145
Potassium (mmol/L)	5.0	3.6–5.1
Bicarbonate (mmol/L)	24	22–32
eGFR (mL/min) > 90	77	➢ 90
Fasting glucose (mmol/L)	9.7*	3.0–7.8
HbA1c (%) (mmol/mol)	7.9	<  6 (42)
Albumin (g/L)	37	33–48
Alanine aminotransferase (U/L)	18	<  45
Aspartate aminotransferase (U/L)	18	<  45
Alkaline phosphatase (U/L)	66	38–126
γ-Glutamyl transferase (U/L)	22	0–30
Bilirubin (umol/L)	6	0–25
Free T4 (pmol/L)	17.3	12–22
Free T3 (pmol/L)	3.5	3.1–6.8
TSH (mIU/L)	1.5	0.27–4.2
Testosterone (nmol/L)	3.3	0–1.7
Androgen free index (%)	12	0–4.6
DHEAS (umol/L)	12.9	2.1–8.7
LH (mIU/ml)	11.3	>  30
FSH (mIU/L)	81.7	20–90
Prolactin (mU/L)	662	102–496
IGF1 (nmol/L)	25	3.8–29.8
Haemoglobin (g/L)	143	115–165
Platelets (× 109/L)	295	150–450
Confirmation of Cushing syndrome
0800 cortisol (nmol/L)	768	155–599
ACTH (pg/mL)	35.1	7.2–63.3
24 h urinary free cortisol (nmol/day)	413	(<  166)
Urine creatinine (24 h)	10	(6.0–18)
Cortisol post 1 mg dexamethasone suppression test (nmol/L)	122	155–599
ACTH post 1 mg dexamethasone suppression test (pg/mL)	18.5	7.2–63.3
Cortisol post 8 mg dexamethasone suppression test (nmol/L)	109	155–599
ACTH post 8 mg dexamethasone suppression test (pg/mL)	12.6	7.2–63.3
BIPSS: Central-to-peripheral ACTH maximal ratio (baseline)	17.4	≥2
BIPSS: Central-to-peripheral ACTH maximal ratio (5 min after CRH stimulation)	9.7	≥3

* ACTH adrenocorticotropic hormone, BIPSS Bilateral inferior petrosal sinus sampling, DHEAS dehydroepiandrosterone sulfate, eGFR estimated glomerular filtration rate, FSH follicle-stimulating hormone, LH luteinising hormone, IGF1 Insulin-like growth factor, TSH thyroid-stimulating hormone; bolded results are outside of the reference range