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. 2019 Jun 29;11:58. doi: 10.1186/s13195-019-0507-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — siRNA repression of SAT1 reduces tau pathology in vitro. a Representative images and quantification of western blot analysis of C3 HeLa cells stably overexpressing tau (4R0N) following transfection with siRNA scramble negative control or siRNA SAT1 (n = 3). b One way analysis of variance (ANOVA) revealed an effect of group on monomeric Tau pSer356 (F(3, 8) = 4.743, p = .035), and post hoc comparisons revealed a significant decrease in response to siRNA SAT1 with and without DSPM (p = .029, p = .010, respectively), compared to siRNA scrambled control. c One way analysis of variance (ANOVA) revealed an effect of group on monomeric Tau pSer396 (F(3, 8) = 15.829, p = .001), and post hoc comparisons revealed a significant decrease in response to siRNA SAT1 with and without DSPM (p = .003, p = .001, respectively), compared to siRNA scrambled control. d One way analysis of variance (ANOVA) revealed no effect of group on monomeric total tau (F(3, 8) = 2.236, p = .161); however, post hoc comparisons revealed a significant decrease in response to siRNA SAT1 without DSPM (p = .05), compared to siRNA scrambled control. One way analysis of variance (ANOVA), followed by post hoc comparisons using Fishers PLSD, *p < .05. Data is represented by means ± S.E.M.