Patient cohorts with corresponding diagnosis as identified by an expert neuropathologist on postsurgical specimens

Site No., Initial Diagnosis	Category	Percentage CRN/Tumor as Identified by Expert	No. of Cases
Site 1
Primary tumors	Predominant tumor	<20% CRN, >80% tumor	12
	Predominant CRN	>80% CRN, <20% tumor	10
Metastatic tumors	Predominant tumor	<20% CRN, >80% tumor	12
	Predominant CRN	>80% CRN, <20% tumor	8
Site 2
Primary tumors	Predominant tumor	<20% CRN, >80% tumor	4
	Predominant CRN	>80% CRN, <20% tumor	1
	Mixed	30% CRN, >70% tumor	2
Metastatic tumors	Predominant tumor	<20% CRN, >80% tumor	1
	Predominant CRN	>80% CRN, <20% tumor	1
	Mixed	50% CRN, 50% tumor	1 (50%)
Site 3
NPC	Pure	100% CRN	13
TCIA
Glioblastoma	Pure	100% Tumor	10

Note:—NPC indicates nasopharyngeal carcinoma.