Table 2.

Glucose, Insulin, GLP-1, and GIP After Fructose or Glucose Drink

	Lean (n = 14)	Obese (n = 23)	P
Fructose drink
Baseline glucose, mg/dL	88.5 ± 0.87	92.0 ± 5.5	0.112
Incremental peak glucose, mg/dL	12.3 ± 8.3	6.8 ± 3.5	<0.001
iAUC glucose, mg/dL⋅min	7472 ± 185.6	7468 ± 134.2	0.986
Baseline insulin, μU/mL	14.6 ± 6.7	34.2 ± 17.3	<0.001
Incremental peak insulin, μU/mL	37.6 ± 17.9	67.0 ± 31.5	0.003
iAUC insulin, μU/mL⋅min	796.1 ± 188.0	1001 ± 164.3	<0.001
Baseline GLP-1, pmol/L	1.49 ± 2.1	4.1 ± 6.3	0.185
Incremental peak GLP-1, pmol/L	1.0 ± 0.7	5.2 ± 6.8	0.028
iAUC GLP-1, pmol/L⋅min	21.0 ± 9.1	253.1 ± 105.7	<0.001
Baseline GIP, pmol/L	65.7 ± 31.0	59.3 ± 26.2	0.505
Incremental peak GIP, pmol/L⋅min	102.3 ± 95.5	75.7 ± 52.1	0.279
iAUC GIP, pmol/L⋅min	2415 ± 1606	1840 ± 666.4	0.136
Glucose drink
Baseline glucose, mg/dL	86.9 ± 5.4	91.4 ± 6.3	0.194
Incremental peak glucose, mg/dL	60.1 ± 26.7	52.7 ± 17.9	0.319
iAUC glucose, mg/dL⋅min	9231 ± 447.1	8689 ± 436.9	0.417
Baseline insulin, μU/mL	14.5 ± 6.0	33.5 ± 16.6	<0.001
Incremental peak insulin, μU/mL	162.5 ± 124.1	232.7 ± 106.3	0.040
iAUC insulin, μU/mL⋅min	5750 ± 1302	9275 ± 1597	<0.001
Baseline GLP-1, pmol/L	1.38 ± 2.1	3.98 ± 6.8	0.194
Incremental peak GLP-1, pmol/L	3.8 ± 2.8	1.8 ± 1.6	0.009
iAUC GLP-1, pmol/L⋅min	95.6 ± 38.4	24.6 ± 25	<0.001
Baseline GIP, pmol/L	92.1 ± 47.7	92.0 ± 47.6	0.999
Incremental peak GIP, pmol/L⋅min	176.8 ± 107.8	217.8 146.8	0.995
iAUC GIP, pmol/L⋅min	6808 ± 1979	8396 ± 2034	0.026

Data are presented as mean ± SD. Incremental values are calculated as the difference from baseline. Boldface indicates P values < 0.05.