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. Author manuscript; available in PMC: 2019 Oct 11.
Published in final edited form as: Mucosal Immunol. 2019 Apr 11;12(4):1004–1012. doi: 10.1038/s41385-019-0164-2

Figure 6: Schema of the mechanism of TNC-mediated HIV-1 neutralization.

Figure 6:

TNC blocks the interaction between the HIV-1 Env and the coreceptor CCR5 / CXCR4 via binding to the HIV-1 Env V3 loop. The fn and fbg domains of individual arms of oligomerized hexameric TNC may contact multiple Envs on the virion surface.