Table 3:
Hill equation parameters.
| Ligand | Hill Fit Paramters (mean ± SD) | ||
|---|---|---|---|
| IC50, μM | ΔV1/2 max, mV | h | |
| DM-PT | 408 ± 55 | -- | -- |
| DE-P | 25.1 ±2.7 | −22.1 ± 1.0 | 1.95 ± 0.44 |
| DE-PIC | 240 ± 20 | -- | -- |
| DE-CH | 2995 ± 723 | -- | -- |
| DIP-P | 5.8 ± 1.2 | −39.8 ± 2.3 | 0.85 ± 0.11 |
| DIP-PT | 22.2 ± 1.8 | -- | -- |
| DIP-PIC | 43.7 ± 3.8 | -- | -- |
| DIP-PF | 267 ± 24 | -- | -- |
| DIP-CH | 35.0 ± 21.0 | −18.9 ± 3.4 | 0.76 ± 0.19 |
| DTB-P | 4.8 ± 0.8 | −42.4 ± 2.8 | 0.97 ± 0.13 |
| DTB-CH | 11.4 ± 4.2 | −9.9 ± 1.5 | 1.28 ± 0.47 |
| DSB-P | 355 ± 38 | -- | -- |
Where not reported, parameters were constrained to those determined for DTB-P as described in Section 2.3 and Figure 3. For all ligands, fitted parameters were significantly different from those of DTB-P and DIP-P (P < 0.05: one-way ANOVA).