Fig. 2.

LXRβ activation by GW3965 reversed CFA-elicited persistent mechanical allodynia and thermal hyperalgesia. a Schematic illustration of the experiment procedure. b, c GW3965 (GW, 10 mg/kg) provided relief of mechanical allodynia on the ipsilateral side and no effect on the contralateral side in CFA-treated mice. d, e GW relieved thermal hyperalgesia on the ipsilateral side and had no effect on the contralateral side in CFA-treated mice. Error bars represent SEM. n = 5, ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 vs. Sham; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 vs. CFA-injected group