Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 29;16:132. doi: 10.1186/s12974-019-1507-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 3 — Knockdown of LXRβ expression in ACC by shLXRβ blocked GW3965-mediated analgesic effects in CFA-injected mice. a The schematic showed the experimental design for virus injection, drug treatment, and behavior tests. b, c LXRα knockdown by shLXRα did not affect GW-mediated analgesia of mechanical allodynia induced by CFA. d, e shLXRβ abolished GW-mediated analgesia of mechanical allodynia induced by CFA. f, g shLXRα did not affect GW-mediated analgesia of thermal hyperalgesia induced by CFA. h, i LXRβ knockdown by shLXRβ abolished GW-mediated analgesia of thermal hyperalgesia induced by CFA. Error bars represent SEM. n = 6, ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 vs. shNC-injected group; ^#p < 0.05, ^##p < 0.01 vs. shNC + CFA group; ^&p < 0.05, ^&&p < 0.01, ^&&&p < 0.001 vs. shLXRα + CFA group