Table 2:
Post-Sepsis Clinical Trajectory Comparisons
| Parameter | Early death (n=4) |
CCI (n=55) |
RAP (n=98) |
P Value* |
|---|---|---|---|---|
| Age, y, median (25th, 75th) | 62 (51, 70) | 65 (58, 72) | 59 (48, 69) | 0.010 |
| Male sex, n (%) | 2 (50) | 36 (65.5) | 47 (48) | 0.045 |
| Race, n (%) | 0.54 | |||
| Black or African American | 1 (25) | 4 (7.3) | 8 (8.2) | |
| White | 3 (75) | 50 (90.9) | 86 (87.8) | |
| Other | 0 (0) | 1 (1.8) | 4 (4.0) | |
| Charlson comorbidity index, median (25th, 75th) | 4.5 (3.5, 6) | 5 (3, 8) | 3.5 (2, 6) | 0.014 |
| Comorbidity, diabetes, n (%) | 1 (25) | 21 (38.2) | 31 (31.6) | 0.38 |
| Inter-facility hospital transfer, n (%) | 3 (75) | 29 (52.7) | 36 (36.7) | 0.032 |
| Sepsis severity, n (%) | ||||
| Sepsis | 1 (25) | 11 (20) | 45 (45.9) | 0.001 |
| Severe sepsis | 0 (0) | 25 (45.5) | 37 (37.8) | |
| Septic shock | 3 (75) | 19 (34.5) | 16 (16.3) | |
| Lactic acid (mmol/L), median (25th, 75th) | 2.5 (1.6, 5.2) | 2 (1.3, 3.6) | 1.6 (1.2, 2.3) | 0.033 |
| APACHE II, median (25th, 75th) | 27 (19, 38) | 21 (15, 26) | 14 (10, 21) | <0.001 |
| Maximum SOFA score, median (25th, 75th) | 17 (11, 22) | 10 (8, 13) | 6 (3, 8) | <0.001 |
| Multiple organ failure†, n (%) | 4 (100) | 43 (78.2) | 32 (32.7) | <0.001 |
| Ventilator days, median (25th, 75th) | 5.5 (5, 10) | 7 (3, 15) | 0 (0, 2) | <0.001 |
| ICU LOS, median (25th, 75th) | 5.5 (5, 9) | 20 (15, 29) | 5 (3, 9) | <0.001 |
| Hospital LOS, median (25th, 75th) | 6 (5.5, 9.5) | 28 (20, 41) | 12 (7, 20) | <0.001 |
| Hospital mortality, n (%) | 4 (100) | 8 (14.5) | 0 (0) | <0.001 |
| Discharge disposition, n (%) | <0.001 | |||
| Good | 0 (0) | 6 (11) | 74 (76) | |
| Home | 0 (0) | 0 (0) | 29 (30) | |
| Rehab | 0 (0) | 1 (1.8) | 3 (3.1) | |
| Home healthcare services | 0 (0) | 5 (9.1) | 42 (43) | |
| Poor disposition | 4 (100) | 49 (89) | 24 (24) | |
| LTAC | 0 (0) | 24 (44) | 1 (1) | |
| SNF | 0 (0) | 7 (13) | 23 (24) | |
| Another inpatient hospital | 0 (0) | 8 (15) | 0 (0) | |
| Hospice | 0 (0) | 5 (9.1) | 0 (0) | |
| Death | 4 (100) | 5 (9.1) | 0 (0) | |
| Six-month mortality, n (%) | 4 (100) | 22 (40) | 5 (5.1) | <0.001 |
*
Comparison of CCI and RAP groups.
†
Denver Multiple Organ Failure score ≥3
SOFA, sequential organ failure assessment score; LOS, length of stay; Rehab, inpatient rehabilitation facility; LTAC, long-term acute care facility; SNF, skilled nursing facility.