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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Nat Methods. 2019 Jun 24;16(7):633–639. doi: 10.1038/s41592-019-0436-5

Figure 4. The LADL-induced engineered loop occurs as early as 4 hours after blue light illumination.

Figure 4.

(a-b) Zoomed in heatmaps corresponding to Box 1 from Figure 3a–b for (a) relative interaction frequency 5C signal and (b) distance-corrected interaction score 5C signal. (c-d) Percent looping efficiency for the Zfp462 promoter and Klf4 SE interaction after (c) 24 hours (n=5 independent experiments) and (d) 4 hours (n=1 experiment) of blue light illumination. Red bars, medians of each condition. P-values computed using the unpaired two-sided Mann Whitney U test. (e) Zoomed in heatmaps corresponding to Box2 from Figure 3a–b for (top) relative interaction frequency 5C signal and (bottom) distance-corrected interaction score 5C signal.