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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Nanomedicine. 2019 Apr 23;19:106–114. doi: 10.1016/j.nano.2019.02.027

Figure 3. Antibody conjugation improves targeting of NPs to specific cells.

Figure 3.

(A) Schematic of the antibody conjugation process using EDC-NHS chemistry. (B) Size and (C) zeta potential changes before and after antibody conjugation. (D) Quantitation of the number of antibodies conjugated to the NP surface with and without EDC chemistry. (E) Comparison of NP uptake and Cre recombination in the aorta, kidney, and heart between unconjugated and anti-CD31 antibody conjugated NPs loaded with OH-Tam within Rosa26CreER;tdTF/+ mice, bar = 50 μm.Inset shows magnified view of boxed regions.