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Preliminary safety evaluation of PEG-ss-aAPP/MTX micelles. Animals were treated intravenously as shown and examined 6 h later. (A) Average body weight of mice during the experiment; values are mean ± SD (n=6). (B-C) Levels of aspartate aminotransferase (AST) and blood urea nitrogen (BUN). (D) Serum concentrations of IL-6.
