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. 2019 Jun 9;9(15):4494–4507. doi: 10.7150/thno.33683

Figure 5.

Figure 5

Identification of tumor-associated exosomal miRNAs as potential biomarkers by the TIRF imaging system. The TIRF images (A) and miR-21-EX numbers (B) at indicated time points in serum samples from nude mice following subcutaneous injection without or with A375 cells (2 × 106 cells per mouse); n = 3 replicates per sample. Scale bar = 3 µm. (C) TIRF imaging analysis of exosomal miR-21 in serum samples from nude mice for tumor treatment monitoring. Tumor-bearing mice were treated with different dosages of DOX at 10 days post-implantation. Serum miR-21-EX levels were also determined by the TIRF assay. (D) Changes in the miR-21-EX serum levels in tumor-bearing mice after treatment without and with DOX. The treatment of tumor-bearing mice started at 25 days post-implantation. The different dosages (20 and 40 mg m-2) of DOX were injected into the abdominal cavity of mice once every 10 days. n = 3 mice per group.