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. 2019 Jun 9;9(15):4308–4323. doi: 10.7150/thno.32710

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© Ivyspring International Publisher

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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Liver-specific RCAN1.4 overexpression alleviates CCl₄-induced liver fibrosis. (A) Representative RCAN1, H&E, Masson, Sirius red, and α-SMA staining of liver tissue sections. (B) Serum ALT and AST levels. (C) Protein and (D) mRNA levels of RCAN1.4, COL1a1 and α-SMA in primary hepatic stellate cells. (E) Protein levels of C-myc, Cyclin D1, Bax, Bcl2, and cleaved-caspase3. ^*p<0.05, ^**p<0.01, ^***p<0.001 compared to the vehicle group,^#p<0.05, ^##p<0.01, ^###p<0.001 compared to rAAV8-empty-treated vehicle group, ^$p<0.05, ^$$p<0.01, ^$$$p<0.001 compared to rAAV8-RCAN1.4-treated vehicle group, ^@p<0.05, ^@@p<0.01, as indicated. For all panels, data represent the mean ± s.e.m. for 3-4 independent experiments.

Liver-specific RCAN1.4 overexpression alleviates CCl₄-induced liver fibrosis. (A) Representative RCAN1, H&E, Masson, Sirius red, and α-SMA staining of liver tissue sections. (B) Serum ALT and AST levels. (C) Protein and (D) mRNA levels of RCAN1.4, COL1a1 and α-SMA in primary hepatic stellate cells. (E) Protein levels of C-myc, Cyclin D1, Bax, Bcl2, and cleaved-caspase3. ^*p<0.05, ^**p<0.01, ^***p<0.001 compared to the vehicle group,^#p<0.05, ^##p<0.01, ^###p<0.001 compared to rAAV8-empty-treated vehicle group, ^$p<0.05, ^$$p<0.01, ^$$$p<0.001 compared to rAAV8-RCAN1.4-treated vehicle group, ^@p<0.05, ^@@p<0.01, as indicated. For all panels, data represent the mean ± s.e.m. for 3-4 independent experiments.