TABLE 3.

Enriched pathways in GO molecular function and biological processes identified using genes from the longitudinal assessment of SPT on DNAm. For molecular functions, all detected pathways are with P-value of 0.091, and for biological processes, the P-values are 0.099

Pathway ID	Name	Raw P-value	FDR P-value	Genes from our study involved in each term
	GO molecular function
GO:0046525	Xylosylprotein 4-beta-galactosyltransferase activity	0.0014		B4GALT7
GO:0039552	RIG-I binding	0.0014		SEC14L1
GO:0004956	Prostaglandin D receptor activity	0.0028		GPR44
GO:0001785	Prostaglandin J receptor activity	0.0028	0.091	GPR44
GO:0004105	Choline-phosphate cytidylyltransferase activity	0.0028		PCYT1A
GO:0004958	Prostaglandin F receptor activity	0.0028		GPR44
GO:0004914	Interleukin-5 receptor activity	0.0028		IL5RA
	GO biological process
GO:0032674	Regulation of interleukin-5 production	0.0004	0.099	EPX, IL5RA
GO:0032634	Interleukin-5 production	0.0004		EPX, IL5RA
GO:0045598	Regulation of fat cell differentiation	0.0006		NCOR2, ZFPM1, METRNL
GO:0002761	Regulation of myeloid leukocyte differentiation	0.0007		FADD, ZFPM1, MITF
GO:0032673	Regulation of interleukin-4 production	0.001		ZFPM1, EPX
GO:0045403	Negative regulation of interleukin-4 biosynthetic process	0.0014		ZFPM1
GO:0036116	Long-chain fatty-acyl-CoA catabolic process	0.0014		ACOT7
GO:2000454	Positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation	0.0014		FADD
GO:0036114	Medium-chain fatty-acyl-CoA catabolic process	0.0014		ACOT7
GO:0072365	Regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter	0.0014		NCOR2
GO:0060377	Negative regulation of mast cell differentiation	0.0014		ZFPM1
GO:1902303	Negative regulation of potassium ion export	0.0014		KCNH2
GO:1900533	Palmitic acid metabolic process	0.0014		ACOT7
GO:1900535	Palmitic acid biosynthetic process	0.0014		ACOT7
GO:0032633	Interleukin-4 production	0.0015		ZFPM1, EPX