Table 5.
Mutations in coding regions detected among in vitro tigecycline-resistant strains.
| Strain | Tigecycline MIC (mg/L) | Product | Coding region change | Amino acid change |
|---|---|---|---|---|
| A1 | 0.06 | - | - | - |
| A11 | 0.125 | - | - | - |
| A20 | 0.5 | iron ABC transporter substrate-binding protein | G943 T | G315* |
| 30S ribosomal protein S10 | C166T | H56Y | ||
| A42 | 1.0 | iron ABC transporter substrate-binding protein | G943 T | G315* |
| 30S ribosomal protein S10 | C166T | H56Y | ||
| translation initiation factor IF-2 | G1514A | G505D | ||
| 50S ribosomal protein S3 | 493_494insGTTCAG | S164E165insGS | ||
| B1 | 0.06 | - | - | - |
| B21 | 0.25 | MarR-family transcriptional regulator | G400A | A134T |
| B42 | 0.5 | MarR-family transcriptional regulator | G400A | A134T |
| PhoB-family transcriptional regulator | A320G | E107G | ||
| 50S ribosomal protein L11 | C76T | P26Ser | ||
| Integrase | T707A | F239L | ||
| 50S ribosomal protein L6 | G196A | G66Arg | ||
| Membrane protein | A1029T | L343F | ||
| C1 | 0.06 | - | - | - |
| C6 | 0.125 | - | - | - |
| C42 | 1.0 | TetM | G1826T | G609V |