Skip to main content
. Author manuscript; available in PMC: 2020 May 3.
Published in final edited form as: Nucl Med Biol. 2019 May 3;71:32–38. doi: 10.1016/j.nucmedbio.2019.04.005

Figure 4. Applicability of the bead-based assay to evaluate the TBF of radioimmunoconjugates that bind shed antigens and small molecule radioligands.

Figure 4.

A) High TBF of [89Zr]Zr-DFO-5B1 (molar activity =13 MBq/nmol) with polyvalent biotinylated CA19.9 antigen; C) Demonstration of the utility of the bead-based assay with small molecule radioligand – [177Lu]Lu-PSMA-617 (molar activity = 2.6 MBq/nmol) showing high (~80%) TBF and minimum NSB at 24 h post radiosynthesis.