Table 1.

Pilot screening of HDAC inhibiton for N^ɛ-acetyl lysine derivatives containing acetyl group with the hybridization of ZBG groups (*100 µM; **10 µM).

*Cmpd	HDAC inhibition (%)	*Cmpd	HDAC inhibition (%)
9	37.5 ± 0.6	14m	14.3 ± 0.5
10	38.7 ± 1.0	14n	16.2 ± 2.0
11	86.0 ± 3.0	14o	48.6 ± 0.5
12	30.7 ± 3.7	14p	24.7 ± 2.8
13	39.3 ± 3.1	14q	36.2 ± 0.4
14a	39.6 ± 0.4	15a	19.4 ± 10.9
14b	39.2 ± 0.8	15b	2.9 ± 0.8
14c	51.0 ± 1.0	15c	7.1 ± 0.3
14d	48.4 ± 4.4	16a	4.0 ± 1.7
14e	54.0 ± 1.9	16b	4.3 ± 0.5
14f	45.0 ± 0.4	16c	1.1 ± 0.4
14g	10.3 ± 4.9	17a	7.0 ± 0.4
l4h	28.3 ± 4.6	17b	69.3 ± 3.4
14i	36.8 ± 1.1	17c	50.6 ± 6.9
14j	12.2 ± 6.5	18b	99.9 ± 0.9
14k	22.4 ± 0.2	18c	109.2 ± 0.5
14l	3.1 ± 0.5	**SAHA (1)	102.2 ± 4.1