Edmonds 1994.

Methods	Method of randomisation: Sealed envelope Assessor blinding: Not mentioned Intention‐to‐treat: No
Participants	Location: Northwick Park Hospital, Harlow, Middlesex, UK Period of study: 1990‐1993 Participant description: Initial episode of Graves' disease. All lived in areas of normal iodine uptake. Diagnosis on basis of TFTs, absence of nodules by palpation, Diffuse increased uptake of 99m Technetium scan Inclusion criteria: Graves' disease as above Exclusion criteria: Pregnancy Sex: M/F: A: 6/28; B: 11/25 Age: mean (SD) A: 48 (11.9); B: 41(12.1) Baseline comparability: No statistically significant differences
Interventions	Description of intervention: A: Block and replace; carbimazole 60 mg for 1 month, then thyroxine to maintain normal free T3 B: Titration of carbimazole (initial dose 60 mg for 1 month) titrated down by clinical evaluation and restoration of free T4 and total T3
Outcomes	Main outcome: Relapse of hyperthyroidism
Study details	Duration of therapy: 12 months Allocated: A: 49; B: 46; Total 95 Completed: A: 34; B: 36 Assessed: A: 34; B: 36 Length of follow‐up: Two years
Publication details	Language of Publication: English Publication status: Peer reviewed journal
Notes	Email from Edmonds 1/9/2006 clarifying details of complications
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Low risk
Allocation concealment?	Low risk
Incomplete outcome data addressed? All outcomes	High risk