Garcia‐Mayor 1992.

Methods	Method of randomisation: No description given Assessor blinding: Not mentioned Intention‐to‐treat: No
Participants	Location: General Hospital of Vigo, Vigo, Spain Period of study: 1984‐1992 Participant description: Patients with Graves' disease. Diagnosis on basis of signs and symptoms, typical thyroid function tests, thyroid antibodies (TRAb over 15U/L), diffuse uptake of 99m technetium scan. Inclusion criteria: Graves' disease as above Exclusion criteria: Pregnancy, enlarged goitre requiring surgery Sex: M/F: Total 12/92 Age (SD): A: 41(14); B: 37 (13) Baseline comparability: No statistically significant differences
Interventions	Description of intervention: A + B: all participants received carbimazole 10 mg t.d.s. till euthyroid, then maintenance dose not less than 10 mg. A: Duration of therapy: 12 months B: Duration of therapy: 24 months
Outcomes	Main outcome: Relapse of hyperthyroidism
Study details	A: Duration of therapy: 12 months B: Duration of therapy: 24 months Allocated: A: 29; B: 27; total 56 eligible Completed: A: 28; B: 24 Assessed: A: 28; B: 24 Length of follow‐up: 5 years post therapy
Publication details	Language of Publication: English Publication status: Peer reviewed journal
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Incomplete outcome data addressed? All outcomes	High risk