Hoermann 2002.

Methods	Method of randomisation: Computer aided randomisation Assessor blinding: No Intention‐to‐treat: Yes
Participants	Location: Multicentre involving 23 sites in Germany, Hungary and Austria. Period of Study: 1996‐1999. Participant description: patients with Graves' disease treated with 12 to 15 months of ATD and stable euthyroid for 6 months. Inclusion criteria: Graves' disease as above. Exclusion criteria: <18 or >70 years. Recurrent disease. ATD less than 12 or greater than 15 months. Steroid or immunosuppressive therapy in past 6 months, Severe disease excluding thyroxine administration (CHD, arrhythmia). Sex M/F: Group A: 16/98, Group B: 13/98. Age(SEM): Group A; 41(1.1), Group B: 41(1.87). Baseline comparability: No statistically significant differences
Interventions	Description of intervention: Randomised after 12 to 15 months of ATD and confirmed euthroid 4 weeks after drug free period. Two groups: Group A: Levothyroxine for 1 year to keep TSH <0.3 and normal FT3 and FT4; Group B: Control, on no medication. At the end of first year: Group 1 was randomised further into groups: 1A: Second year of levothyroxine, 2A: Stop levothyroxine
Outcomes	Main outcome: Relapse of hyperthyroidism
Study details	Duration of therapy: 1 year Allocated: A: 114; B: 111 Completed at 1 year: A: 94;B: 98 Assessed at 1 year: A: 94;B: 98 Duration of Follow‐up: 1 year
Publication details	Language of Publication: English Publication status: Peer reviewed journal
Notes	Email communication with authors February 2004
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Low risk
Allocation concealment?	Low risk
Blinding? All outcomes	High risk
Incomplete outcome data addressed? All outcomes	Low risk