Jorde 1995.

Methods	Method of randomisation: No description given Assessor blinding: Not mentioned Intention‐to‐treat: Yes
Participants	Location: University Hospital of Tromso, Norway Period of study: 1987‐1994 Participant description: Initial episode of Graves' disease. All patients had thyroid ultrasound. Any doubtful cases had a 99m technetium scan Inclusion criteria: Graves disease as above Exclusion criteria: Pregnancy, large goitres, eye symptoms requiring steroids, other serious diseases Sex: M/F: A: 6/21; B: 5/24 Age: mean (SD) A: 40.6(2.1); B: 43.8 (2.8) Baseline comparability: No statistically significant differences
Interventions	Description of intervention: A: Titration of methimazole (Initial dose 15 mg b.d.) titrated down with checks every 2‐4 weeks to a mean dose of 7.5 mg daily B: Block and replace; methimazole 30 mg b.d., thyroxine added after 2‐4 weeks
Outcomes	Main outcome: Relapse of hyperthyroidism
Study details	Duration of therapy: 6 months Allocated: A: 27; B: 29 Completed: A: 22; B: 19 Assessed: A: 22; B: 19 Length of follow‐up: 24 months
Publication details	Language of Publication: English Publication status: Peer reviewed journal
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Incomplete outcome data addressed? All outcomes	Low risk