Nedrebo 2002.

Methods	Method of randomisation: No description given. Assessor blinding: Not done. Intention to treat: Yes
Participants	Location: Four Hospitals in Norway. Period of study: Jan 1997 to July 1999 Participant description: Inclusion criteria: Graves' disease, age 16‐75 years. Exclusion criteria: Pregnancy, ATD in prior 12 months, Allergy to ATD, Ongoing immunosuppression, Non compliance because of psychiatric or other illness Sex: Overall M/F: 30/188 Age (mean, SD): Group 1A: 43.9 (10.2); Group 1B: 40.2 (11.5); Group 2A: 42.4(12.2); Group 2B: 43.4 (13.3) Duration of follow up: 13.4‐41.7 months
Interventions	Description of intervention: Both groups had antithyroid medication (carbimazole mainly with propylthiouracil in six participants) for 12 months. Group 1 had Block and replace regimen. Group 2 had titration regimen. For the subsequent 12 months Groups 1A and 2A had thyroxine alone and Group 1B and 2B had no treatment.
Outcomes	Main outcome: Relapse of hyperthyroidism
Study details	Duration of therapy: 2 years Allocated: 1A: 54, 1B: 56, 2A: 54, 2B: 54 Completed: 1A: 47, 1B: 51, 2A: 46, 2B: 45 Assessed: 1A: 47, 1B: 51, 2A: 46, 2B: 45 Duration of follow up: 13.4‐41.7 months
Publication details	Language of Publication: English Publication status: Peer reviewed journal
Notes	Email contact with author for clarification of numbers, February 2004
Risk of bias
Bias	Authors' judgement	Support for judgement
Blinding? All outcomes	High risk
Incomplete outcome data addressed? All outcomes	Low risk