Birk 2000.

Methods	RCT (4 groups) MT vs. MT+ XS vs. MT+ BFB vs. control
Participants	42 male and female adults (27‐50); HIV+, no AIDS symptoms; non‐hospitalised.
Interventions	Group 1: MT 12/52 1xpw for 45 min (Swedish type, whole body) n=8 Group 2: MT a/a plus aerobic exercise (supervised 2x pw) n=7 Group 3: MT a/a plus biofeedback stress reduction 1xpw n=8 Group 4: Control ‐ standard care (no MT) n=8
Outcomes	6D QoL; CD4, CD8 and NKC counts; CD4/8 ratio.
Notes	MT+BFB favourably increases health perceptions and reduces health care utilisation (p<0.05), compared to single/other modalities or control. No other significant findings.
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	High risk	Sequence generation was not specified.
Allocation concealment?	High risk	Not reported
Blinding? All outcomes	High risk	Not reported
Free of selective reporting?	Low risk
Free of other bias?	High risk	Baseline comparison between groups not done.