Manabe 2015.

Methods	Prospective, double‐masked randomised controlled trial Country: Japan
Participants	Number: 62 people (66 eyes) Age: average 60 years (range 20 to 82) Sex: 82% male Inclusion criteria: Diagnosed as having an indication for primary vitrectomy because of persistent vitreous haemorrhage for over 3 months and TRD caused by PDR; or fundus findings of proliferative changes or vitreous haemorrhage in people with iris neovascularisation or neovascular glaucoma Exclusion criteria: Intraocular surgery or retinal photocoagulation within 3 months before the study Intravitreal injection of drugs or sub‐Tenon injection of steroids within 3 months before the study Cerebrovascular infarction or myocardial infarction within 3 months before the study
Interventions	Intervention: IVB 0.16 mg/0.05 ml) 1 day before vitrectomy (n= 32) Comparator: Sham injection 1 day before vitrectomy (n=34)
Outcomes	Primary outcome: Frequency of reoperation due to postoperative recurrent vitreous haemorrhage within 4 weeks after vitrectomy Secondary outcome measures: Numbers of intraoperative laser and endodiathermy spots Frequency of postoperative recurrent vitreous haemorrhage within 4 weeks after vitrectomy Concentration of VEGF in vitreous at the beginning of surgery
Notes	Trial registration number: NCT01854593 Date study conducted: June 2012 to August 2013 Funding: not reported Conflict of interest: reported "none"
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not reported
Allocation concealment (selection bias)	Low risk	"...were randomised using the envelop method" "Both the investigators and patients were masked to the treatment assignment".
Blinding of participants and personnel (performance bias) All outcomes	Low risk	"Both the investigators and patients were masked to the treatment assignment".
Blinding of outcome assessment (detection bias) All outcomes	Low risk	"All postoperative examinations were performed by three vitreoretinal surgeons (H.S., T.H., H.N.) who also were masked to the study group allocation".
Incomplete outcome data (attrition bias) All outcomes	Low risk	All randomised participants were followed up for 1 month
Selective reporting (reporting bias)	Low risk	All outcomes on trial registry entry reported