| Methods | RCT (Randomised Controlled Trial); multicentre (Northen Europe: Sweden, Norway, Denmark) | |
| Participants | Patients undergoing curative resection of TNM stage II‐III colorectal cancer (n=2224) | |
| Interventions | 2‐arm trials: patients randomized to: A) surgery alone (n=1121), or B) postoperative adjuvant chemotherapy with 5‐FU based regimens (n=1103) | |
| Outcomes | Overall survival (OS) | |
| Notes | Data are presented as a meta‐analysis of RCT conducted in Northen Europe. In this meta‐analysis we compared patients with rectal cancer randomized to adjuvant chemotherapy (n=339) versus those with rectal cancer randomized to observation (n=352) Chemotherapy regimens: 1) 5‐FU + levamisole; 2) 5‐FU + leucovorin; 3) 5‐FU + leucovorin + levamisole |
|
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Blinding (performance bias and detection bias) All outcomes | Low risk | |
| Selective reporting (reporting bias) | Low risk | |
| Other bias | Low risk | |
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