| Methods | RCT (Randomised Controlled Trial); multicentre (Japan) | |
| Participants | Patients with TNM stage II‐III colorectal cancer undergoing apparently radical surgery of the primary tumour (n=170) | |
| Interventions | 2‐arm trial: patients were randomly assigned to: A) surgery alone (n=83), or B) postoperative chemotherapy (n=87) with HCFU (1‐hexylcarbamoyl‐5‐fluorouracil, an oral fluoropyrimidine) | |
| Outcomes | Disease‐free survival (DFS) and overall survival (OS) | |
| Notes | For this meta‐analysis, patients with rectal cancer treated with surgery alone (n=40) were compared to those undergoing surgery + adjuvant chemotherapy (n=37) | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Allocation concealment (selection bias) | Low risk | Randomization by telephone |
| Selective reporting (reporting bias) | Low risk | |
| Other bias | Low risk | |
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