| Methods | RCT (Randomised Controlled Trial); multicentre (USA) | |
| Participants | Patients undergoing curative resection of Dukes´B and C (TNM stage II‐III) rectal cancer (n=202) | |
| Interventions | 4‐arm trial: patients were randomized to: A) surgery alone (n=58), or B) adjuvant chemotherapy (n=48), or C) adjuvant radiotherapy (n=50), or D) adjuvant radio‐chemotherapy (n=46) Chemotherapy: 5‐FU + semustine |
|
| Outcomes | Disease‐free survival (DFS) and overall survival (OS) | |
| Notes | No stratification between B and C In this meta‐analysis we compared patients randomized to adjuvant chemotherapy (n=48) versus those randomized to surgery alone (n=58) |
|
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Allocation concealment (selection bias) | Unclear risk | B ‐ Unclear |
| Selective reporting (reporting bias) | Low risk | |
| Other bias | Low risk | |
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