Brue 2001

Methods	Parallel trial of omega‐3 PUFA versus a dietary supplement
Participants	Inclusion criteria: children diagnosed with DSM IV ADHD‐combined type by a physician or psychologist Exclusion criteria: serious pre‐existing medical or psychological condition or stimulant medication other than Ritalin Mean age: 8.4 years, gender (at follow‐up): 44 boys and 7 girls, loss to follow‐up: 9/60 Baseline scores: not stated Setting: US
Interventions	This was the second of 2 12‐week trials. In this second trial an omega‐3 PUFA in combination with a dietary supplement (given to the group who received a single dietary supplement in trial 1) was compared to a double dose of the dietary supplement (placebo group in trial 1). Both were given twice a day for 12 weeks. Omega‐3 PUFA Flax seed (rich in omega‐3 PUFA) 100 mg plus single dietary supplement: Ginkgo biloba 10 mg, Melissa officialis 200 mg, grapine 30 mg, dimethylaminoethanol 35 mg, l‐glutamine 100 mg Double dietary supplement: Ginkgo biloba 20 mg, Melissa officialis 400 mg, grapine 60 mg, dimethylaminoethanol 70 mg, l‐glutamine 200mg
Outcomes	ADHD symptoms Parent and teacher‐rated Conners Rating Scales (revised: long form): inattentive and hyperactive‐impulsive subscales measured at 12 weeks
Notes	Participant numbers were not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not stated
Allocation concealment (selection bias)	Unclear risk	Not stated
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Parents and teachers did not know what the participant was allocated until the trial was completed. Only the trial physician had access to this information.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Data collectors did not know what the participants were allocated until the trial was completed
Incomplete outcome data (attrition bias) All outcomes	High risk	9 children were lost to follow‐up but it is not clear what sample numbers were used in the analysis
Selective reporting (reporting bias)	Low risk	All outcomes appear to have been reported
Other bias	Unclear risk	Baseline characteristics of each group were not reported. The PUFA group had received an additional 12 weeks of dietary supplement before this second trial was started.