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. 2019 Jun 24;14:4503–4515. doi: 10.2147/IJN.S193583

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© 2019 Wang et al.

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FMT and CpG synergistically inhibit tumor growth in a nude mouse xenograft model. (A) Image of tumors harvested at the end of treatment. (B) Tumor growth curves of tumor-bearing mice. (C) Body weight of tumor-bearing mice during the experiment. (D) Ki-67 and EGFR expression of tumor cells detected by immunohistochemistry. Scale bar: 50 μm. (E) Quantitative analysis of (D). (F) Macrophages stained with F4/80 and iNOS in tumor tissues detected by immunohistochemistry. Scale bar: 50 μm. Results are expressed as mean ± SDof three independent experiments. **P<0.01, ***P<0.001 vs control.

Abbreviation: EGFR, epidermal growth factor receptor; FMT, ferumoxytol.