Fig. 1. Orientation of the thyroid core needle biopsy. (A) Normal thyroid tissue is noted on the left lower corner (blue arrow). (B) Less than half near the normal thyroid tissue is defined as ‘peripheral’ (red arrow, A). (C) More than half distance from the normal thyroid tissue is defined as ‘central’ (black arrow, A) with focal remaining benign follicular lesion on the central side (H&E stain, ×100).