Fig. 2.

Three weeks of chronic unpredictable stress induces anxiety-like behavior and working memory deficits. Mice that received three weeks of chronic unpredictable stress spent significantly less time in the open zones of the elevated plus maze (panel A) indicating an anxious-like state. Stressed mice also displayed working memory deficits as made evident by reduced overall spontaneous alternations (panel B). *p < 0.05, relative to non-stressed mice. n = 24 stressed mice compared to 8 controls. All data is expressed as mean ± SEM.