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. 2018 Oct 26;32(8):1112–1121. doi: 10.5713/ajas.18.0540

Figure 2.

Figure 2

LPS exposure increases the TLR4 mRNA level, p-p38 MAPK protein level, and production of the proinflammatory cytokines IL-1β, TNF-α, and IL-6. (A) TLR4 transcript levels in bovine COCs. (B) Production of IL-1β, TNF-α, and IL-6 after exposure to LPS. (C) and (D) Western blot analysis of p-p38 MAPK and p-38 protein levels. LPS, lipopolysaccharide; TLR4, toll-like receptor 4; p-p38 MAPK, phosphorylation of p38 mitogen-activated protein kinase; IL, interleukin; TNF-α, tumor necrosis factor-α; COCs, cumulus-oocyte complexes. Asterisk indicates significant difference (p<0.05).