Figure 2.

Amphiregulin contributes to wound healing by releasing local, bioactive transforming growth factor (TGF)β. Upon tissue damage, tissue‐resident macrophages sense the breach of tissue homeostasis and release Amphiregulin, which activates the local release of bio‐active TGFβ. This local release of bio‐active TGFβ induces the differentiation of local pericyte populations into myofibroblasts, which produce extracellular matrix components essential for the restoration of blood barrier function and the restoration of tissue homeostasis. AREG, Amphiregulin; ECM, extracellular matrix.