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. 2019 Jun 4;20(11):2734. doi: 10.3390/ijms20112734

Figure 3.

Figure 3

Effect of skullcapflavone II on MMP-1 transcription in foreskin fibroblasts. (A) MMP-1 mRNA levels in DMSO- or skullcapflavone II-treated foreskin fibroblasts were determined using real-time RT-PCR. * p < 0.05 vs. the sample incubated with 0 μM skullcapflavone II. (B) Foreskin fibroblasts were transiently co-transfected with pGL3-MMP-1 promoter and pRL-TK as a transfection control. Cells were treated overnight with 3 μM skullcapflavone II. Luciferase activity was determined as the ratio of firefly/Renilla luciferase activity. The activity of the MMP-1 promoter in the presence of skullcapflavone II relative to that in the absence of skullcapflavone II is shown. *p < 0.05 vs. the sample incubated with 0 μM skullcapflavone II.