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Alternative splicing of VEGF-A. Splicing at the proximal splicing site (PSS) is stimulated by serine-arginine protein kinase 1 (SRPK1), and results in the pro-angiogenic VEGF165a splice variant. Clk1/4 stimulates splicing at the distal splicing site (DSS), which results in the anti-angiogenic VEGF165b isoform.
