TABLE 1.

HHV-6B peptides with CD4 T-cell responses detected in this study

ORF	Positions	Amino acid sequencea	HLA restriction	Previously reportedb
U14	372–389	EYDEDKPPIQVDPGRVDN		Yes
U14	379–396	PIQVDPGRVDNVLTDSDF		Yes
U90	281–298	KQELLESRNEIIENHVKN		Yes
U90	309–326	QMNQIFMDNsDKTFLKIH		No
U90	316–333	DNsDKTFLKIHINsKNLI		Yes
U90	330–347	KNLITAAKNIGIAVLQSI		Yes
U90	344–361	LQSIVLsSNEFSWQYLKP		Yes
U90	365–382	QFKITMMNMITHAsEsIE		Yes
U90	876–893	KTHKVDNsVIHSSAKMNV	DPB1*04:02	Yes
U90	904–921	HsFINHFVPIKTDDEEYE		Yes
U90	911–928	VPIKTDDEEYEKENVSYT	DPB1*04:02	Yes
U90	939–956	LEDITPTKKLITEMVMEN		Yes
U90	946–963	KKLITEMVMENFMDLTDI	DQ	Yes
U90	967–984	GIAKHsQDLSSKYTVITH		Yes
U90	974–991	DLSSKYTVITHTAsEKNL	DQ	No
U90	981–998	VITHTAsEKNLNVANSQN		No
U90	1002–1019	AETQIFDPQGTGNNSPIL		Yes
U90	1009–1026	PQGTGNNSPILNIINDTT		Yes
U90	1016–1033	SPILNIINDTTsQNDENR		Yes
U90	1023–1040	NDTTsQNDENRsTEGTSN	DRB1*03:01	No
U90	1037–1054	GTSNDNEKsTIRSDsNSD		Yes
U90	1044–1061	KsTIRSDsNSDKMEVFKL	DP	Yes
U95	1–18	MSSNLEDLLWQQILSMDP		No
U95	8–25	LLWQQILSMDPAELLSDN		No
U95	15–32	SMDPAELLSDNAISSTSD		No
U95	85–102	TGLSLESINNQINVQPTQ		No
U95	92–109	INNQINVQPTQMTFQPIS		No
U95	99–116	QPTQMTFQPISPPMQGQN		No
U95	729–746	KRMHSEIGISEDGRVREE		No
U95	785–802	QDASGGSSSGTKKGEKLQ		No
U95	848–865	NPDYRQAKRLLADIPYRR		No
U95	855–872	KRLLADIPYRRWIPDTFN		No
U95	862–879	PYRRWIPDTFNMEEHEGP		No
U95	876–893	HEGPFLPIVTRPPTVFMG		No
U95	904–921	SVTSIGPLSKLTYFKELL		No
U95	939–956	AKHRVYIMSEEKLGYNHI		No

^aA lowercase “s” denotes a serine substitution for cysteine.

^bEpitopes were previously described by Vita et al. (65) or Becerra-Artiles et al. (35).