TABLE 1.
Number of infected birds, 50% bird infectious dose, mortality, and seroconversion in chickens inoculated by the intrachoanal route or contact exposed with three H7N3 HPAI viruses from 2012, 2015, and 2016
| Virus | Inoculated birds (n = 5) |
Contact-exposed birds |
||||||
|---|---|---|---|---|---|---|---|---|
| Virus dose (log10 EID50) | No. of infected birds/total no. of birds inoculateda | BID50 (log10 EID50)b | Mortality (MDT)c | Serologyd | No. of infected birds/total no. of birds | Mortality (MDT)c | Serologyd | |
| A/CK/JL/12 | 2 | 0/5 | 3.0 | 0/5 | 0/5 | 0/3 | 0/3 | 0/3 |
| 4 | 5/5 | 5/5 (2) | NA | 1/3 | 1/3 (4) | 0/2 | ||
| 6 | 5/5 | 5/5 (2) | NA | 0/3 | 0/3 | 0/3 | ||
| A/CK/PB/15 | 2 | 1/5 | 2.8 | 1/5 (3) | 0/4 | 0/3 | 0/3 | 0/3 |
| 4 | 5/5 | 5/5 (2.8) | NA | 0/3 | 0/3 | 0/3 | ||
| 6 | 5/5 | 5/5 (2.8) | NA | 0/3 | 0/3 | 0/3 | ||
| A/CK/PB/16 | 2 | 0/5 | 3.0 | 0/5 | 0/5 | 0/3 | 0/3 | 0/3 |
| 4 | 5/5 | 5/5 (2.6) | NA | 0/3 | 0/3 | 0/3 | ||
| 6 | 5/5 | 5/5 (2) | NA | 0/3 | 0/3 | 0/3 | ||
a
Number of chickens infected/total number of birds inoculated; determined by qRRT-PCR and serology.
b
BID50, 50% bird infectious dose.
c
Number of dead birds/total number of birds inoculated (days postinoculation). MDT, mean death time (days post-virus exposure).
d
Number of birds with positive antibody titers/total number of birds that survived. NA, not applicable (because all died).